Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II.

ABSTRACT:

Background

Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear.

Methods

We included 28,250 women in the Nurses' Health Study II who provided data on physical activity during adolescence (ages 12-22 years) in 1997 and underwent lower bowel endoscopy (1998-2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life.

Results

Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjus

SUBMITTER: Rezende LFM 

PROVIDER: S-EPMC6738055 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature