Clinical implications of heterogeneity in PD-L1 immunohistochemical detection in hepatocellular carcinoma: the Blueprint-HCC study.
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SUBMITTER: Pinato DJ
PROVIDER: S-EPMC6738063 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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Clinical implications of heterogeneity in PD-L1 immunohistochemical detection in hepatocellular carcinoma: the Blueprint-HCC study.
Pinato David J DJ Mauri Francesco A FA Spina Paolo P Cain Owen O Siddique Abdul A Goldin Robert R Victor Stephane S Pizio Corinna C Akarca Ayse U AU Boldorini Renzo L RL Mazzucchelli Luca L Black James R M JRM Shetty Shishir S Marafioti Teresa T Sharma Rohini R
British journal of cancer 20190507 11
Programmed cell death ligand-1 immunohistochemical detection (PD-L1 IHC) is a putative predictor of response to PD-1/PD-L1-targeted checkpoint inhibitors. However, there is no gold standard assay in hepatocellular carcinoma (HCC). We evaluated 5 PD-L1 IHC assay platforms (E1LN3, 28-8, 22c3, SP263 and SP142) in 100 HCCs reporting PD-L1 expression in malignant (M) and tumour-infiltrating immune cells (TICs) and non-tumorous cirrhotic tissues (NTICs). We found substantial inter-assay heterogeneity ...[more]
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