Ontology highlight
ABSTRACT:
SUBMITTER: Shen S
PROVIDER: S-EPMC6738529 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Shen Suqin S Feng Huan H Le Yichen Y Ni Jun J Yu Long L Wu Jiaxue J Bai Meirong M
Cell cycle (Georgetown, Tex.) 20190729 18
Aurora-A is a serine/threonine kinase, which is overexpressed in multiple human cancers and plays a key role in tumorigenesis and tumor development. In this study, we found that the receptor of activated C-kinase1 (RACK1), an important regulator of biological functions, interacted with Aurora-A and co-localized with Aurora-A at centrosomes. Moreover, RACK1 induces the auto-phosphorylation of Aurora-A in vitro and in vivo. Depletion of RACK1 impaired the activation of Aurora-A in late G2 phase, t ...[more]