Dataset Information

Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort.

ABSTRACT:

Purpose

Data for elucidating post-kidney transplantation (KT) acute pancreatitis (AP) risk are limited and no large-scale cohort study has investigated the impact of AP after KT.

Method

Data from Taiwan National Health Insurance (NHI) Research Database (NHIRD) were calculated through the method of propensity score matching to compare the pancreatitis risk in patients with and without KT.

Results

The overall pancreatitis incidence rates were 1.71 and 0.61 per 1,000 person-years in the KT and non-KT groups, respectively and corresponding adjusted HR (aHR [95% CI]) for pancreatitis was 2.48 (1.51-4.09) in the KT group. In the multivariable model, AP risk was higher in transplant patients with alcohol-related illnesses (aHR: 3.78, 95% CI: 1.32-10.8), gall stone disease (aHR: 3.53, 95% CI: 1.48-8.44), or past history of pancreatitis (aHR: 10.3, 95% CI: 5.08-20.8). Of note, recurrent AP risk was significantly higher in the KT group (aHR: 8.19, 95% CI: 2.89-23.2). Patients with post-KT AP demonstrated shorter patient and allograft survival than did those without (both P < 0.001, respectively).

Conclusion

In conclusion, KT recipients are very likely to be associated with AP. Moreover, their inferior outcomes are strongly associated with post-KT AP.

SUBMITTER: Chuang YW

PROVIDER: S-EPMC6738600 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort.

Chuang Ya-Wen YW Huang Shih-Ting ST Yu Tung-Min TM Li Chi-Yuan CY Chung Mu-Chi MC Lin Cheng-Li CL Chang Chi-Sen CS Wu Ming-Ju MJ Kao Chia-Hung CH

PloS one 20190911 9

<h4>Purpose</h4>Data for elucidating post-kidney transplantation (KT) acute pancreatitis (AP) risk are limited and no large-scale cohort study has investigated the impact of AP after KT.<h4>Method</h4>Data from Taiwan National Health Insurance (NHI) Research Database (NHIRD) were calculated through the method of propensity score matching to compare the pancreatitis risk in patients with and without KT.<h4>Results</h4>The overall pancreatitis incidence rates were 1.71 and 0.61 per 1,000 person-ye ...[more]

PMID: 31509567

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Project description:IMPORTANCE:Potential effects of breast feeding on children's behaviour remains an elusive debate given inherent methodological challenges. Propensity score matching affords benefits by ensuring greater equivalence on observable social and health determinants, helping to reduce bias between groups. OBJECTIVES:We examined whether the duration of breast feeding had an impact on children's externalising and internalising behaviours. STUDY DESIGN:A cohort study (Encuesta Longitudinal de la Primera Infancia cohort) that included 3037 Chilean families who were enrolled in 2010. Follow-up data was collected in 2012. SETTING:General community. PARTICIPANTS:Population-based sample. Eligibility criteria: children born full-term with complete data on matching variables. Matching variables included: healthcare system as a proxy of income, presence of a partner/spouse in the household, maternal age, educational level, IQ, working status, type of work, diagnosis of prenatal depression by a healthcare professional, smoking during pregnancy, delivery type, child sex, weight at birth, incubation following delivery, and child age. EXPOSURE:Duration of breast feeding. MAIN OUTCOMES AND MEASURES:Externalising and internalising problems assessed using the Child Behaviour Checklist. RESULTS:Matched results revealed benefits of any breast feeding, up to 6 months, on emotional reactivity and somatic complaints (mean difference of -1.00, 95% CI, -1.84 to -0.16 and -1.02, 95% CI, -1.76 to -0.28, respectively). Children breast fed between 7 and 12 months also had reduced scores on emotional reactivity, in addition to attention problems (mean difference of -0.86, 95% CI, -1.66 to -0.06 and -0.50, 95% CI, -0.93 to -0.07, respectively). No benefits were observed for children breast fed 13 months or more. CONCLUSION:Reduced internalising difficulties and inattention were found in children breast fed up to a year, suggesting that breast feeding may have beneficial impacts on these areas of development. The magnitude of effect was modest. Extended durations of breast feeding did not appear to offer any benefits.

Dataset Information

Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort.

Purpose

Method

Results

Conclusion

Publications

Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort.

Similar Datasets

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