Dataset Information

Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study.

ABSTRACT:

Objectives

Upper body fat has been associated with an unfavourable cardiometabolic risk. We aimed to investigate the associations between mid-upper arm circumference (MUAC), a novel indicator of upper body fat, and a wide spectrum of cardiometabolic risk profiles in Chinese population.

Design and setting

Cross-sectional analyses were performed using data from a well-defined community in 2014, Shanghai, China.

Participants

A total of 6287 Chinese adults (2310 men and 3977 women) aged 40 years or older.

Outcome measures

Multivariable logistic regression model was used to examine the associations of MUAC with cardiometabolic disorders including central obesity, diabetes, hypertension, hypertriglyceridaemia, low high-density lipoprotein (HDL) cholesterol and subclinical atherosclerosis.

Results

In the overall participants, after multivariable adjustment, each 1 SD (3.13?cm) increment in MUAC was positively associated with central obesity (OR 2.05; 95%?CI 1.85 to 2.28), hypertension (OR 1.10; 95%?CI 1.03 to 1.19) and low HDL cholesterol (OR 1.10; 95%?CI 1.01 to 1.22). Multivariable-adjusted ORs for subclinical atherosclerosis were gradually increased across increasing quartiles of MUAC with the lowest quartile as reference (quartile 2: OR 1.31; 95%?CI 1.09 to 1.58; quartile 3: OR 1.33; 95% CI 1.10 to 1.62; quartile 4: OR 1.45; 95% CI 1.16 to 1.80; p for trend=0.005). Similar but more prominent associations were observed among women than men. In addition, MUAC was significantly interacted with diabetes (p for interaction=0.04) and insulin resistance (p for interaction=0.01) on subclinical atherosclerosis.

Conclusion

A greater MUAC was positively associated with higher risks of several cardiometabolic disorders and subclinical atherosclerosis in Chinese adults.

SUBMITTER: Hou Y

PROVIDER: S-EPMC6738736 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study.

Hou Yanan Y Jia Xu X Xuan Liping L Zhu Wen W Deng Chanjuan C Wang Long L Zhao Zhiyun Z Li Mian M Lu Jieli J Xu Yu Y Chen Yuhong Y Wang Weiqing W Bi Yufang Y Xu Min M Wang Tiange T

BMJ open 20190908 9

<h4>Objectives</h4>Upper body fat has been associated with an unfavourable cardiometabolic risk. We aimed to investigate the associations between mid-upper arm circumference (MUAC), a novel indicator of upper body fat, and a wide spectrum of cardiometabolic risk profiles in Chinese population.<h4>Design and setting</h4>Cross-sectional analyses were performed using data from a well-defined community in 2014, Shanghai, China.<h4>Participants</h4>A total of 6287 Chinese adults (2310 men and 3977 wo ...[more]

PMID: 31501106

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Project description:Background/objectivesAccurate, early identification of acutely malnourished children has the potential to reduce related child morbidity and mortality. The current World Health Organisation (WHO) guidelines classify non-oedematous acute malnutrition among children under five using Mid-Upper Arm Circumference (MUAC) or Weight-for-Height Z-score (WHZ). However, there is ongoing debate regarding the use of current MUAC cut-offs. This study investigates the diagnostic performance of MUAC to identify children aged 6-24 months with global (GAM) or severe acute malnutrition (SAM).Subjects/methodsCross-sectional, secondary data from a community sample of children aged 6-24 months in Niger were used for this study. Children with complete weight, height and MUAC data and without clinical oedema were included. Using WHO guidelines for GAM (WHZ < -2, MUAC < 12.5 cm) and SAM (WHZ < -3, MUAC < 11.5 cm), the sensitivity (Se), specificity (Sp), predictive values, Youden Index and Receiver Operating Characteristic (ROC) curves were calculated for MUAC when compared with the WHZ reference criterion.ResultsOf 1161 children, 23.3% were diagnosed with GAM using WHZ, and 4.4% with SAM. Using current WHO cut-offs, the Se of MUAC to identify GAM was greater than for SAM (79 vs. 57%), yet the Sp was lower (84 vs. 97%). From inspection of the ROC curve and Youden Index, Se and Sp were maximised for MUAC < 12.5 cm to identify GAM (Se 79%, Sp 84%), and MUAC < 12.0 cm to identify SAM (Se 88%, Sp 81%).ConclusionsThe current MUAC cut-off to identify GAM should continue to be used, but when screening for SAM, a higher cut-off could improve case identification. Community screening for SAM could use MUAC < 12.0 cm followed by appropriate treatment based on either MUAC < 11.5 cm or WHZ < -3, as in current practice. While the practicalities of implementation must be considered, the higher SAM MUAC cut-off would maximise early case-finding of high-risk acutely malnourished children.

Dataset Information

Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study.

Objectives

Design and setting

Participants

Outcome measures

Results

Conclusion

Publications

Association between mid-upper arm circumference and cardiometabolic risk in Chinese population: a cross-sectional study.

Similar Datasets

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