Ontology highlight
ABSTRACT:
SUBMITTER: Thair SA
PROVIDER: S-EPMC6738761 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Thair Simone A SA Topchiy Elena E Boyd John H JH Cirstea Mihai M Wang Catherine C Nakada Taka-Aki TA Fjell Christopher D CD Wurfel Mark M Russell James A JA Walley Keith R KR
Journal of innate immunity 20150909 1
During septic shock, tumor necrosis factor alpha (TNFα) is an early response gene and induces a plethora of genes and signaling pathways. To identify robust signals in genes reliably upregulated by TNFα, we first measured microarray gene expression in vitro and searched methodologically comparable, publicly available data sets to identify concordant signals. Using tag single-nucleotide polymorphisms in the genes common to all data sets, we identified a genetic variant of the TNFAIP2 gene, rs8126 ...[more]