Ontology highlight
ABSTRACT:
SUBMITTER: Goel PN
PROVIDER: S-EPMC6739141 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Goel Peeyush N PN Moharrer Yasaman Y Hebb John H JH Egol Alexander J AJ Kaur Gurpreet G Hankenson Kurt D KD Ahn Jaimo J Ashley Jason W JW
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20190624 10
Owing to the central role of osteoclasts in bone physiology and remodeling, manipulation of their maturation process provides a potential therapeutic strategy for treating bone diseases. To investigate this, we genetically inhibited the Notch signaling pathway in the myeloid lineage, which includes osteoclast precursors, using a dominant negative form of MAML (dnMAML) that inhibits the transcriptional complex required for downstream Notch signaling. Osteoclasts derived from dnMAML mice showed no ...[more]