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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.

ABSTRACT: The HIV type-1 nonnucleoside reverse transcriptase inhibitor, efavirenz, is widely used to treat HIV type-1 infection. Efavirenz is predominantly metabolized into inactive metabolites by cytochrome P450 (CYP)2B6, and patients with certain CYP2B6 genetic variants may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation. We summarize the evidence from the literature and provide therapeutic recommendations for efavirenz prescribing based on CYP2B6 genotypes.

SUBMITTER: Desta Z

PROVIDER: S-EPMC6739160 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.

Desta Zeruesenay Z Gammal Roseann S RS Gong Li L Whirl-Carrillo Michelle M Gaur Aditya H AH Sukasem Chonlaphat C Hockings Jennifer J Myers Alan A Swart Marelize M Tyndale Rachel F RF Masimirembwa Collen C Iwuchukwu Otito F OF Chirwa Sanika S Lennox Jeffrey J Gaedigk Andrea A Klein Teri E TE Haas David W DW

Clinical pharmacology and therapeutics 20190705 4

The HIV type-1 nonnucleoside reverse transcriptase inhibitor, efavirenz, is widely used to treat HIV type-1 infection. Efavirenz is predominantly metabolized into inactive metabolites by cytochrome P450 (CYP)2B6, and patients with certain CYP2B6 genetic variants may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation. We summarize the evidence from the literature and provide therapeutic recommendations for efavirenz prescribing bas ...[more]

PMID: 31006110

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