Ontology highlight
ABSTRACT:
SUBMITTER: Hanson A
PROVIDER: S-EPMC6739162 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Hanson Amanda A Piras Ignazio S IS Wilhelmsen Danielle D Still Christopher D CD Chu Xin X Petrick Anthony A Gerhard Glenn S GS DiStefano Johanna K JK
Cytokine 20190725
CCL20 (CC chemokine ligand 20) is emerging as an important regulatory molecule in a pathway common to virus infection, alcoholic hepatitis, and non-alcoholic fatty liver disease (NAFLD) leading to the development of hepatic fibrosis. We previously observed upregulation of CCL20 in patients with NAFLD fibrosis and human hepatic stellate cells (LX-2 cells) in response to lipid loading. To date, the mechanisms mediating the relationship between CCL20 and hepatic fibrogenesis remain unknown. In this ...[more]