Ontology highlight
ABSTRACT:
SUBMITTER: Kahremany S
PROVIDER: S-EPMC6739180 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Kahremany Shirin S Sander Christopher Lane CL Tochtrop Gregory P GP Kubas Adam A Palczewski Krzysztof K
Organic & biomolecular chemistry 20190828 35
Catalytic Z-isomerization of retinoids to their thermodynamically less stable Z-isomer remains a challenge. In this report, we present a photochemical approach for the catalytic Z-isomerization of retinoids using monochromatic wavelength UV irradiation treatment. We have developed a straightforward approach for the synthesis of Z-retinoids in high yield, overcoming common obstacles normally associated with their synthesis. Calculations based on density functional theory (DFT) have allowed us to ...[more]