Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population.

ABSTRACT: The exact etiology of dementia is still unclear, but both genetic and lifestyle factors are thought to be key drivers of this complex disease. The recognition of familial patterns of dementia has led to the discovery of genetic factors that have a role in the pathogenesis of dementia, including the apolipoprotein E (APOE) genotype and a large and still-growing number of genetic variants^1,2. Beyond genetic architecture, several modifiable risk factors have been implicated in the development of dementia³. Prevention trials of measures to halt or delay cognitive decline are increasingly recruiting older individuals who are genetically predisposed to dementia. However, it remains unclear whether targeted health and lifestyle interventions can attenuate or even offset incr

SUBMITTER: Licher S 

PROVIDER: S-EPMC6739225 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature