Ontology highlight
ABSTRACT:
SUBMITTER: Lin CC
PROVIDER: S-EPMC6739295 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lin Chia-Cheng CC Chin Yu-Tang YT Shih Ya-Jung YJ Chen Yi-Ru YR Chung Yao-Yu YY Lin Chi-Yu CY Hsiung Chao-Nan CN Whang-Peng Jacqueline J Lee Sheng-Yang SY Lin Hung-Yun HY Davis Paul J PJ Wang Kuan K
Journal of dental sciences 20190327 3
<h4>Background/purpose</h4>Dysregulation of cell cycle checkpoint control may lead to the independence of growth regulating signals. Checkpoint protein such as the PD-1/PD-L1 immune checkpoint involving tumor cells and host immune defense lymphocytes is a well-studied therapeutic target in oncology. Acting at a cell surface receptor on plasma membrane integrin αvβ3, thyroxine stimulates intracellular accumulation of PD-L1 in cancer cells. Although resveratrol also binds to integrin αvβ3, it redu ...[more]