Ontology highlight
ABSTRACT:
SUBMITTER: Benedicto A
PROVIDER: S-EPMC6739321 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Benedicto Aitor A Herrero Alba A Romayor Irene I Marquez Joana J Smedsrød Bård B Olaso Elvira E Arteta Beatriz B
Scientific reports 20190911 1
The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs), implicated in tumor adhesion and angiogenesis, we performed in vitro cocultures and an in vivo model of liver metastasis of colorectal cancer (CRC). ICAM-1 blockade in the LSECs decreased the adhesion and transmigration of tumor cells ...[more]