Ontology highlight
ABSTRACT:
SUBMITTER: Zhang SB
PROVIDER: S-EPMC6739334 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190911 1
Circular RNAs are non-coding RNAs, and are enriched in the CNS. Dorsal horn neurons of the spinal cord contribute to pain-like hypersensitivity after nerve injury in rodents. Here we show that spinal nerve ligation is associated with an increase in expression of circAnks1a in dorsal horn neurons, in both the cytoplasm and the nucleus. Downregulation of circAnks1a by siRNA attenuates pain-like behaviour induced by nerve injury. In the cytoplasm, we show that circAnks1a promotes the interaction be ...[more]