Metabolomics Deciphered Metabolic Reprogramming Required for Biofilm Formation.
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ABSTRACT:
SUBMITTER: Lu H
PROVIDER: S-EPMC6739361 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Metabolomics Deciphered Metabolic Reprogramming Required for Biofilm Formation.
Lu Haitao H Que Yumei Y Wu Xia X Guan Tianbing T Guo Hao H
Scientific reports 20190911 1
Biofilm formation plays a key role in many bacteria causing infections, which mostly accounts for high-frequency infectious recurrence and antibiotics resistance. In this study, we sought to compare modified metabolism of biofilm and planktonic populations with UTI89, a predominant agent of urinary tract infection, by combining mass spectrometry based untargeted and targeted metabolomics methods, as well as cytological visualization, which enable us to identify the driven metabolites and associa ...[more]
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