Surface association sensitizes Pseudomonas aeruginosa to quorum sensing.
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ABSTRACT:
SUBMITTER: Chuang SK
PROVIDER: S-EPMC6739362 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Surface association sensitizes Pseudomonas aeruginosa to quorum sensing.
Chuang Sara K SK Vrla Geoffrey D GD Fröhlich Kathrin S KS Gitai Zemer Z
Nature communications 20190911 1
In the pathogen Pseudomonas aeruginosa, LasR is a quorum sensing (QS) master regulator that senses the concentration of secreted autoinducers as a proxy for bacterial cell density. Counterintuitively, previous studies showed that saturating amounts of the LasR ligand, 3OC12-HSL, fail to induce the full LasR regulon in low-density liquid cultures. Here we demonstrate that surface association, which is necessary for many of the same group behaviors as QS, promotes stronger QS responses. We show th ...[more]
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