Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen VH
PROVIDER: S-EPMC6739821 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nguyen Vinh H VH Singh Noreen N Medina Ana A Usón Isabel I Fraser Marie E ME
Protein science : a publication of the Protein Society 20190827 10
ATP-citrate lyase (ACLY) catalyzes production of acetyl-CoA and oxaloacetate from CoA and citrate using ATP. In humans, this cytoplasmic enzyme connects energy metabolism from carbohydrates to the production of lipids. In certain bacteria, ACLY is used to fix carbon in the reductive tricarboxylic acid cycle. The carboxy(C)-terminal portion of ACLY shows sequence similarity to citrate synthase of the tricarboxylic acid cycle. To investigate the roles of residues of ACLY equivalent to active site ...[more]