Ontology highlight
ABSTRACT:
SUBMITTER: Yu FH
PROVIDER: S-EPMC6740763 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Yu Frank H FH Westenbroek Ruth E RE Silos-Santiago Inmaculada I McCormick Kimberly A KA Lawson Deborah D Ge Pei P Ferriera Holly H Lilly Jeremiah J DiStefano Peter S PS Catterall William A WA Scheuer Todd T Curtis Rory R
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030801 20
The principal alpha subunit of voltage-gated sodium channels is associated with auxiliary beta subunits that modify channel function and mediate protein-protein interactions. We have identified a new beta subunit termed beta4. Like the beta1-beta3 subunits, beta4 contains a cleaved signal sequence, an extracellular Ig-like fold, a transmembrane segment, and a short intracellular C-terminal tail. Using TaqMan reverse transcription-PCR analysis, in situ hybridization, and immunocytochemistry, we s ...[more]