Ontology highlight
ABSTRACT:
SUBMITTER: Jennewein MF
PROVIDER: S-EPMC6741440 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell 20190613 1
Despite the worldwide success of vaccination, newborns remain vulnerable to infections. While neonatal vaccination has been hampered by maternal antibody-mediated dampening of immune responses, enhanced regulatory and tolerogenic mechanisms, and immune system immaturity, maternal pre-natal immunization aims to boost neonatal immunity via antibody transfer to the fetus. However, emerging data suggest that antibodies are not transferred equally across the placenta. To understand this, we used syst ...[more]