Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi T
PROVIDER: S-EPMC6741575 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Hayashi Tsuyoshi T Watanabe Chiaki C Suzuki Yasushi Y Tanikawa Taichiro T Uchida Yuko Y Saito Takehiko T
Journal of innate immunity 20130713 1
Mammalian melanoma differentiation-associated gene-5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) selectively sense double-stranded RNA (dsRNA) according to length, as well as various RNA viruses to induce an antiviral response. RIG-I, which plays a predominant role in the induction of antiviral responses against influenza virus infection, has been considered to be lacking in chicken, putting the function of chicken MDA5 (chMDA5) under the spotlight. Here, we show that chMDA5, unlike mammal ...[more]