Ontology highlight
ABSTRACT:
SUBMITTER: Olde Nordkamp MJ
PROVIDER: S-EPMC6741594 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Olde Nordkamp Marloes J M MJ Boross Peter P Yildiz Cafer C Jansen J H Marco JH Leusen Jeanette H W JH Wouters Diana D Urbanus Rolf T RT Hack C Erik CE Meyaard Linde L
Journal of innate immunity 20131101 3
Activation of complement may cause severe tissue damage in antibody-mediated allograft rejection and other antibody-mediated clinical conditions; therefore, novel potent complement inhibitors are needed. Previously, we described binding of the inhibitory receptor LAIR-1 and its soluble family member LAIR-2 to collagen. Here, we investigated binding of LAIR-1 and LAIR-2 to the complement proteins C1q and MBL, which both have collagen-like domains, and evaluated the effect of this binding on compl ...[more]