Dataset Information

Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status.

ABSTRACT:

Background

Obesity and metabolic syndrome (MetS) are associated with high risk of cardiac dysfunction and heart failure. We assessed the effect of obesity and metabolic health status on left ventricular (LV) structure and function in subjects without overt heart disease.

Methods

In 789 subjects (58.8±13.0 years, 50.7% males) without overt heart disease, LV morphology and function were compared among 6 groups stratified by body mass index (BMI) (normal weight, overweight and obese) and metabolic health status (meeting ?1 criterion of MetS excluding waist circumference defined as metabolically healthy; otherwise, metabolically unhealthy).

Results

LV ejection fraction (LVEF) was not different among the 6 groups (P>0.05). However, high BMI and poor metabolic health were associated with poorer global longitudinal strain (GLS), higher LV mass index (LVMI) and higher E/e' (P<0.001). Poor metabolic health status was associated with greater adverse changes in LV structure and function than obesity, and among MetS components, high systolic blood pressure (SBP) showed the greatest impact. Higher SBP, BMI and triglycerides were independently associated with worse GLS, and higher SBP was also associated with worse LVMI and E/e´. GLS, LVMI and E/e´ worsened in proportion to the number of MetS criteria or continuous MetS scores. Adverse myocardial changes associated with obesity were significant in the metabolically healthy group, but not in the metabolically unhealthy group.

Conclusions

Obesity and poor metabolic health status were associated with subclinical decrement in LV systolic and diastolic function, and higher LV mass, but not with LVEF, in subjects without overt heart disease.

SUBMITTER: Lee HJ

PROVIDER: S-EPMC6742457 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status.

Lee Hyun-Jung HJ Kim Hack-Lyoung HL Lim Woo-Hyun WH Seo Jae-Bin JB Kim Sang-Hyun SH Zo Joo-Hee JH Kim Myung-A MA

PloS one 20190912 9

<h4>Background</h4>Obesity and metabolic syndrome (MetS) are associated with high risk of cardiac dysfunction and heart failure. We assessed the effect of obesity and metabolic health status on left ventricular (LV) structure and function in subjects without overt heart disease.<h4>Methods</h4>In 789 subjects (58.8±13.0 years, 50.7% males) without overt heart disease, LV morphology and function were compared among 6 groups stratified by body mass index (BMI) (normal weight, overweight and obese) ...[more]

PMID: 31513625

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Dataset Information

Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status.

Background

Methods

Results

Conclusions

Publications

Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status.

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