Ontology highlight
ABSTRACT:
SUBMITTER: Buffalo CZ
PROVIDER: S-EPMC6742535 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Cell host & microbe 20190822 3
Tetherin is a host defense factor that physically prevents virion release from the plasma membrane. The Nef accessory protein of simian immunodeficiency virus (SIV) engages the clathrin adaptor AP-2 to downregulate tetherin via its DIWK motif. As human tetherin lacks DIWK, antagonism of tetherin by Nef is a barrier to simian-human transmission of non-human primate lentiviruses. To determine the molecular basis for tetherin counteraction, we reconstituted the AP-2 complex with a simian tetherin a ...[more]