Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6742632 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wang Yuhua Y Pandey Ram Naresh RN York Allen J AJ Mallela Jaya J Nichols William C WC Hu Yueh-Chiang YC Molkentin Jeffery D JD Wikenheiser-Brokamp Kathryn A KA Hegde Rashmi S RS
Nature communications 20190912 1
In pulmonary hypertension vascular remodeling leads to narrowing of distal pulmonary arterioles and increased pulmonary vascular resistance. Vascular remodeling is promoted by the survival and proliferation of pulmonary arterial vascular cells in a DNA-damaging, hostile microenvironment. Here we report that levels of Eyes Absent 3 (EYA3) are elevated in pulmonary arterial smooth muscle cells from patients with pulmonary arterial hypertension and that EYA3 tyrosine phosphatase activity promotes t ...[more]