Ontology highlight
ABSTRACT:
SUBMITTER: van de Vondervoort IIGM
PROVIDER: S-EPMC6742634 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
van de Vondervoort Ilse I G M IIGM Amiri Houshang H Bruchhage Muriel M K MMK Oomen Charlotte A CA Rustogi Nitin N Cooper Jason D JD van Asten Jack J A JJA Heerschap Arend A Bahn Sabine S Williams Steven C R SCR Buitelaar Jan K JK Poelmans Geert G Glennon Jeffrey C JC
Translational psychiatry 20190912 1
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with childhood onset, and is characterized by intrusive thoughts and fears (obsessions) that lead to repetitive behaviors (compulsions). Previously, we identified insulin signaling being associated with OCD and here, we aim to further investigate this link in vivo. We studied TALLYHO/JngJ (TH) mice, a model of type 2 diabetes mellitus, to (1) assess compulsive and anxious behaviors, (2) determine neuro-metabolite levels by 1 H ma ...[more]