Ontology highlight
ABSTRACT:
SUBMITTER: Martin JA
PROVIDER: S-EPMC6742638 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190912 1
Persistent transcriptional and morphological events in the nucleus accumbens (NAc) and other brain reward regions contribute to the long-lasting behavioral adaptations that characterize drug addiction. Opiate exposure reduces the density of dendritic spines on medium spiny neurons of the NAc; however, the underlying transcriptional and cellular events mediating this remain unknown. We show that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc. Using vi ...[more]