Ontology highlight
ABSTRACT:
SUBMITTER: Shao X
PROVIDER: S-EPMC6743470 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20190612 17
Maintaining tissue integrity during epidermal morphogenesis depends on α-catenin, which connects the cadherin complex to F-actin. We show that the adhesion modulation domain (AMD) of <i>Caenorhabditis elegans</i> HMP-1/α-catenin regulates its F-actin-binding activity and organization of junctional-proximal actin in vivo. Deleting the AMD increases F-actin binding in vitro and leads to excess actin recruitment to adherens junctions in vivo. Reducing actin binding through a compensatory mutation i ...[more]