Ontology highlight
ABSTRACT:
SUBMITTER: Saliani M
PROVIDER: S-EPMC6743616 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Saliani Mahsa M Jalal Razieh R Ahmadian Mohammad Reza MR
Cancer biology & medicine 20190801 3
Among the numerous oncogenes involved in human cancers, KRAS represents the most studied and best characterized cancer-related genes. Several therapeutic strategies targeting oncogenic KRAS (KRAS <sup><i>onc</i></sup> ) signaling pathways have been suggested, including the inhibition of synthetic lethal interactions, direct inhibition of KRAS <sup><i>onc</i></sup> itself, blockade of downstream KRAS <sup><i>onc</i></sup> effectors, prevention of post-translational KRAS <sup><i>onc</i></sup> modi ...[more]