Ontology highlight
ABSTRACT:
SUBMITTER: Ma RSY
PROVIDER: S-EPMC6743634 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ma Renee Siu Yu RSY Kayani Kayani K Whyte-Oshodi Danniella D Whyte-Oshodi Aiyesha A Nachiappan Nitish N Gnanarajah Shaene S Mohammed Raihan R
Journal of pain research 20190909
Being maladaptive and frequently unresponsive to pharmacotherapy, chronic pain presents a major unmet clinical need. While an intact central nervous system is required for conscious pain perception, nociceptor hyperexcitability induced by nerve injury in the peripheral nervous system (PNS) is sufficient and necessary to initiate and maintain neuropathic pain. The genesis and propagation of action potentials is dependent on voltage-gated sodium channels, in particular, Nav1.7, Nav1.8 and Nav1.9. ...[more]