Effects of a rifampicin pre-treatment on linezolid pharmacokinetics.
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ABSTRACT:
SUBMITTER: Okazaki F
PROVIDER: S-EPMC6743782 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Effects of a rifampicin pre-treatment on linezolid pharmacokinetics.
Okazaki Fumiyasu F Tsuji Yasuhiro Y Seto Yoshihiro Y Ogami Chika C Yamamoto Yoshihiro Y To Hideto H
PloS one 20190913 9
Linezolid is an oxazolidinone antibiotic that effectively treats methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Since rifampicin induces other antibiotic effects, it is combined with linezolid in therapeutic regimes. However, linezolid blood concentrations are reduced by this combination, which increases the risk of the emergence of antibiotic-resistant bacteria. We herein demonstrated that the combination of linezolid with rifampicin inhibited its ...[more]
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