Ontology highlight
ABSTRACT:
SUBMITTER: Kowatsch C
PROVIDER: S-EPMC6744280 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Kowatsch Christiane C Woolley Rachel E RE Kinnebrew Maia M Rohatgi Rajat R Siebold Christian C
Current opinion in structural biology 20190624
The Hedgehog (HH) signalling pathway is a cell-cell communication system that controls the patterning of multiple tissues during embryogenesis in metazoans. In adults, HH signals regulate tissue stem cells and regenerative responses. Abnormal signalling can cause birth defects and cancer. The HH signal is received on target cells by Patched (PTCH1), the receptor for HH ligands, and then transmitted across the plasma membrane by Smoothened (SMO). Recent structural and biochemical studies have poi ...[more]