Dataset Information

Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear.

ABSTRACT: Revealing the mechanisms underlying the reversible physiology of hibernation could have applications to both human and animal health as hibernation is often associated with disease-like states. The present study uses RNA-sequencing to reveal the tissue and seasonal transcriptional changes occurring in grizzly bears (Ursus arctos horribilis). Comparing hibernation to other seasons, bear adipose has a greater number of differentially expressed genes than liver and skeletal muscle. During hyperphagia, adipose has more than 900 differentially expressed genes compared to active season. Hibernation is characterized by reduced expression of genes associated with insulin signaling, muscle protein degradation, and urea production, and increased expression within muscle protein anabolic pathways. Across all three tissues we find a subset of shared differentially expressed genes, some of which are uncharacterized, that together may reflect a common regulatory mechanism. The identified gene families could be useful for developing novel therapeutics to treat human and animal diseases.

SUBMITTER: Jansen HT

PROVIDER: S-EPMC6744400 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear.

Jansen Heiko T HT Trojahn Shawn S Saxton Michael W MW Quackenbush Corey R CR Evans Hutzenbiler Brandon D BD Nelson O Lynne OL Cornejo Omar E OE Robbins Charles T CT Kelley Joanna L JL

Communications biology 20190913

Revealing the mechanisms underlying the reversible physiology of hibernation could have applications to both human and animal health as hibernation is often associated with disease-like states. The present study uses RNA-sequencing to reveal the tissue and seasonal transcriptional changes occurring in grizzly bears (<i>Ursus arctos horribilis</i>). Comparing hibernation to other seasons, bear adipose has a greater number of differentially expressed genes than liver and skeletal muscle. During hy ...[more]

PMID: 31531397

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Dataset Information

Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear.

Publications

Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear.

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