Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6744433 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhang Xixi X Zhang Haiwei H Xu Chengxian C Li Xiaoming X Li Ming M Wu Xiaoxia X Pu Wenjuan W Zhou Bin B Wang Haikun H Li Dali D Ding Qiurong Q Ying Hao H Wang Hui H Zhang Haibing H
Nature communications 20190913 1
The ubiquitination status of RIPK1 is considered to be critical for cell fate determination. However, the in vivo role for RIPK1 ubiquitination remains undefined. Here we show that mice expressing RIPK1<sup>K376R</sup> which is defective in RIPK1 ubiquitination die during embryogenesis. This lethality is fully rescued by concomitant deletion of Fadd and Ripk3 or Mlkl. Mechanistically, cells expressing RIPK1<sup>K376R</sup> are more susceptible to TNF-α induced apoptosis and necroptosis with more ...[more]