A common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins.
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ABSTRACT:
SUBMITTER: Botkjær JA
PROVIDER: S-EPMC6744435 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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A common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins.
Bøtkjær Jane Alrø JA Noer Pernille Rimmer PR Oxvig Claus C Yding Andersen Claus C
Scientific reports 20190913 1
Pregnancy-associated plasma protein-A (PAPP-A) is a key regulator of insulin-like growth factor (IGF) bioactivity, by releasing the IGFs from their corresponding IGF-binding proteins (IGFBPs). The minor allele of the single nucleotide polymorphism (SNP), rs7020782 (serine < tyrosine), in PAPPA has previously been associated with recurrent pregnancy loss as well as with significant reduced levels of PAPP-A protein in human ovarian follicles. The aim of the present study was to reveal a possible f ...[more]
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