Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.
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ABSTRACT:
SUBMITTER: Chen YF
PROVIDER: S-EPMC6744457 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.
Chen Yi-Fan YF Lin I-Hsuan IH Guo Yu-Ru YR Chiu Wei-Jun WJ Wu Mai-Szu MS Jia Wei W Yen Yun Y
Scientific reports 20190913 1
Renal diseases impose considerable health and economic burdens on health systems worldwide, and there is a lack of efficient methods for the prevention and treatment due to their complexity and heterogeneity. Kidneys are organs with a high demand for energy produced by mitochondria, in which Rrm2b has critical functions as reported. The Rrm2b kidney-specific knockout mice we generated exhibited age-dependent exacerbated features, including mitochondrial dysfunction and increased oxidative stress ...[more]
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