Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XN
PROVIDER: S-EPMC6744458 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhang Xiao-Nan XN Cheng Qinqin Q Chen Jingwen J Lam Albert T AT Lu Yanran Y Dai Zhefu Z Pei Hua H Evdokimov Nikolai M NM Louie Stan G SG Zhang Yong Y
Nature communications 20190913 1
Nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP-ribosylation (PARylation). Here we explore chemical and chemoenzymatic synthesis of NAD<sup>+</sup> analogues with ribose functionalized by terminal alkyne and azido groups. Our results demonstrate that azido substitution at 3'-OH of nic ...[more]