Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC6744996 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Yang Hailing H Shu Zhang Z Jiang Yongying Y Mao Weiqun W Pang Lan L Redwood Abena A Jeter-Jones Sabrina L SL Jennings Nicholas B NB Ornelas Argentina A Zhou Jinhua J Rodriguez-Aguayo Cristian C Bartholomeusz Geoffrey G Iles LaKesla R LR Zacharias Niki M NM Millward Steven W SW Lopez-Berestein Gabriel G Le Xiao-Feng XF Ahmed Ahmed A AA Piwnica-Worms Helen H Sood Anil K AK Bast Robert C RC Lu Zhen Z
Clinical cancer research : an official journal of the American Association for Cancer Research 20190807 18
<h4>Purpose</h4>Paclitaxel is an integral component of primary therapy for breast and epithelial ovarian cancers, but less than half of these cancers respond to the drug. Enhancing the response to primary therapy with paclitaxel could improve outcomes for women with both diseases.<b>Experimental Design:</b> Twelve kinases that regulate metabolism were depleted in multiple ovarian and breast cancer cell lines to determine whether they regulate sensitivity to paclitaxel in Sulforhodamine B assays. ...[more]