Ontology highlight
ABSTRACT:
SUBMITTER: Ramme AP
PROVIDER: S-EPMC6745596 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Ramme Anja Patricia AP Koenig Leopold L Hasenberg Tobias T Schwenk Christine C Magauer Corinna C Faust Daniel D Lorenz Alexandra K AK Krebs Anna-Catharina AC Drewell Christopher C Schirrmann Kerstin K Vladetic Alexandra A Lin Grace-Chiaen GC Pabinger Stephan S Neuhaus Winfried W Bois Frederic F Lauster Roland R Marx Uwe U Dehne Eva-Maria EM
Future science OA 20190910 8
Microphysiological systems play a pivotal role in progressing toward a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ models were predifferentiated from induced pluripotent stem cells from the same healthy donor and integrated into the microphysiological system. The coculture of the four autologous tissue models in one common medium deprived of tissue specific growth ...[more]