Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.
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ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC6745702 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.
Zhang Rong R Earnest James T JT Kim Arthur S AS Winkler Emma S ES Desai Pritesh P Adams Lucas J LJ Hu Gaowei G Bullock Christopher C Gold Beth B Cherry Sara S Diamond Michael S MS
Cell reports 20190901 10
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. To determine its role in pathogenesis, we generated mice with mutant Mxra8 alleles: an 8-nucleotide deletion that produces a truncated, soluble form (Mxra8<sup>Δ8/Δ8</sup>) and a 97-nucleotide deletion that abolishes Mxra8 expression (Mxra8<sup>Δ97/Δ97</sup>). Mxra8<sup>Δ8/Δ8</sup> and Mxra8<sup>Δ97/Δ97</sup> fibroblasts show reduced ...[more]
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