Ontology highlight
ABSTRACT:
SUBMITTER: Stavropoulou V
PROVIDER: S-EPMC6745998 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Stavropoulou Vaia V Almosailleakh Marwa M Royo Hélène H Spetz Jean-François JF Juge Sabine S Brault Laurent L Kopp Patrick P Iacovino Michelina M Kyba Michael M Tzankov Alexandar A Stadler Michael B MB Cazzaniga Gianni G Peters Antoine H F M AHFM Schwaller Juerg J
HemaSphere 20180612 4
Previous retroviral and knock-in approaches to model human t(11;19)<sup>+</sup> acute mixed-lineage leukemia in mice resulted in myeloproliferation and acute myeloid leukemia not fully recapitulating the human disease. The authors established a doxycycline (DOX)-inducible transgenic mouse model "<i>iMLL-ENL</i>" in which induction in long-term hematopoietic stem cells, lymphoid primed multipotent progenitor cells, multipotent progenitors (MPP4) but not in more committed myeloid granulocyte-macro ...[more]