Ontology highlight
ABSTRACT:
SUBMITTER: Resendez A
PROVIDER: S-EPMC6746081 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Resendez Angel A Tailor Dhanir D Graves Edward E Malhotra Sanjay V SV
ACS medicinal chemistry letters 20190723 9
Surgical resection and radiotherapy are an effective treatment in many head and neck squamous cell carcinomas (HNSCC), but in others, the development of radiotherapy resistance limits treatment efficacy and permits disease progression. We developed a novel multiwell radiation dosing method to increase the throughput of our investigation of the activity of a novel podophyllotoxin SU093 in acting as a radiosensitizer in the HNSCC models FaDu and SCC-25. These <i>in vitro</i> studies showed that co ...[more]