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Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.

ABSTRACT: The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.

SUBMITTER: Serrano MG

PROVIDER: S-EPMC6746180 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.

Serrano Myrna G MG Parikh Hardik I HI Brooks J Paul JP Edwards David J DJ Arodz Tom J TJ Edupuganti Laahirie L Huang Bernice B Girerd Philippe H PH Bokhari Yahya A YA Bradley Steven P SP Brooks Jamie L JL Dickinson Molly R MR Drake Jennifer I JI Duckworth Robert A RA Fong Stephen S SS Glascock Abigail L AL Jean Sophonie S Jimenez Nicole R NR Khoury Joseph J Koparde Vishal N VN Lara Ana M AM Lee Vladimir V Matveyev Andrey V AV Milton Sarah H SH Mistry Shreni D SD Rozycki Sarah K SK Sheth Nihar U NU Smirnova Ekaterina E Vivadelli Stephany C SC Wijesooriya N Romesh NR Xu Jie J Xu Ping P Chaffin Donald O DO Sexton Amber L AL Gravett Michael G MG Rubens Craig E CE Hendricks-Muñoz Karen D KD Jefferson Kimberly K KK Strauss Jerome F JF Fettweis Jennifer M JM Buck Gregory A GA

Nature medicine 20190529 6

The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or ...[more]

PMID: 31142850

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Project description:Human microbiota plays an indispensable role in physiology, nutrition and most significantly, in imparting immunity. The role of microbiota has remained cryptic for years, until recently meticulous studies revealed the interaction and dynamics of these microbial communities. This diversified state is governed by hormonal, behavioral and physio-chemical changes in the genital tract. Many inclusive studies have revealed "Lactobacillus" to be the most dominant member of vaginal flora in most of the healthy, reproductive age group and pregnant females. A total of five community state types have been described, out of which four are dominated by Lactobacillus while the fifth one by facultative or strict anaerobic species. A variation between species stability and gestational age has also been revealed. Studies have divulged a significant higher stability of vaginal microbiota in early stages of pregnancy and the same increased subsequently. Inter-species and racial variation has shown women belonging to White, Asian, and Caucasian race to harbor more of the anaerobic flora. The vaginal microbiome in pregnancy play a significant role in preterm and spontaneous labor. This Lactobacillus-rich microbiome falls tremendously, becoming more diverse in post-partum period. Apart from these known bacterial communities in human vagina, other microbial communities have also been traced. The major fragment is constituted by vaginal viral virome and very little information exists in relation to vaginal mycobiome. Studies have revealed the abundance of ds DNA viruses in vaginal microbiome, followed by ssDNA, and few unidentified viruses. The eukaryotic viruses detected were very few, with Herpesvirales, and Papillomaviridae being the only pathogenic ones. This flora is transmitted to infants either via maternal gut, vagina or breast milk. Recent studies have given an insight for vaginal microbiome, dissociating the old concept of "healthy" and "diseased." However, more extensive studies are required to study evolution of virome and mycobiome in relation to their association with bacterial communities; to establish and decode full array of vaginal virome under the influence of genotypic and environmental factors, using novel bioinformatic, multi-omic, statistical model, and CRISPR/Cas approaches.

Dataset Information

Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.

Publications

Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.

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