Ontology highlight
ABSTRACT:
SUBMITTER: Rosas R
PROVIDER: S-EPMC6746189 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Rosas Ricardo R Huang Xi-Ping XP Roth Bryan L BL Dockendorff Chris C
ACS medicinal chemistry letters 20190813 9
The concept recently postulated by Stein and co-workers (<i>Science</i> <b>2017</b>, <i>355</i>, 966) that mu opioid receptor (MOR) agonists possessing amines with attenuated basicity show pH-dependent activity and can selectively act at damaged, low pH tissues has been additionally supported by in vitro studies reported here. We synthesized and tested analogs of fentanyl possessing one or two fluorine atoms at the beta position of the phenethylamine side chain, with additional fluorines optiona ...[more]