Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study.

ABSTRACT:

Objective

To develop and validate an integrative system to predict long term kidney allograft failure.

Design

International cohort study.

Setting

Three cohorts including kidney transplant recipients from 10 academic medical centres from Europe and the United States.

Participants

Derivation cohort: 4000 consecutive kidney recipients prospectively recruited in four French centres between 2005 and 2014. Validation cohorts: 2129 kidney recipients from three centres in Europe and 1428 from three centres in North America, recruited between 2002 and 2014. Additional validation in three randomised controlled trials (NCT01079143, EudraCT 2007-003213-13, and NCT01873157).

Main outcome measure

Allograft failure (return to dialysis or pre-emptive retransplantation).

SUBMITTER: Loupy A 

PROVIDER: S-EPMC6746192 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature