Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: a modelling study.

ABSTRACT:

Background

Fungal infections remain a major contributor to the opportunistic infections that affect people living with HIV. Among them, histoplasmosis is considered neglected, often being misdiagnosed as tuberculosis, and is responsible for numerous deaths in Latin America. The objective of this study was to estimate the burden of HIV-associated histoplasmosis compared with tuberculosis in Latin American countries.

Methods

For this modelling study, we estimated prevalence of previous exposure to Histoplasma capsulatum, HIV-associated histoplasmosis annual incidence, and number of deaths in 2012 in Latin American countries based on historical histoplasmin skin test studies in the general population, with an antigen dilution level of more than 1/10. Studies were identified in

SUBMITTER: Adenis AA 

PROVIDER: S-EPMC6746313 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature