Ontology highlight
ABSTRACT:
SUBMITTER: Mizia JC
PROVIDER: S-EPMC6746326 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Mizia J Colin JC Bennett Clay S CS
Organic letters 20190715 15
The first synthesis of the pentasaccharide fragment of the angucycline antibiotic saquayamycin Z is described. By using our sulfonyl chloride mediated reagent controlled dehydrative glycosylation, we are able to assemble the glycosidic linkages with high levels of anomeric selectivity. The total synthesis was completed in 25 total steps, and in 2.5% overall yield with a longest linear sequence of 15 steps. ...[more]