Ontology highlight
ABSTRACT:
SUBMITTER: Seo JB
PROVIDER: S-EPMC6746433 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature metabolism 20181119 1
Decreased adipose tissue oxygen tension and increased HIF-1α expression can trigger adipose tissue inflammation and dysfunction in obesity. Our current understanding of obesity-associated decreased adipose tissue oxygen tension is mainly focused on changes in oxygen supply and angiogenesis. Here, we demonstrate that increased adipocyte O<sub>2</sub> demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia. Deletion of adipocyte <i>Ant2</i> improves obesity-induced intracellu ...[more]