Ontology highlight
ABSTRACT:
SUBMITTER: Park HK
PROVIDER: S-EPMC6746689 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Park Hyung Kyu HK Yu Dan Bi DB Sung Minjung M Oh Ensel E Kim Mingi M Song Ji-Young JY Lee Mi-Sook MS Jung Kyungsoo K Noh Ka-Won KW An Sungbin S Song Kyoung K Nam Do-Hyun DH Kim Yu Jin YJ Choi Yoon-La YL
Journal of molecular medicine (Berlin, Germany) 20190718 10
Solitary fibrous tumors (SFTs) are NAB2-STAT6 fusion-associated neoplasms. There are several subtypes of NAB2-STAT6 fusions, but their clinical significances are still unclear. Moreover, the mechanisms of malignant progression are also poorly understood. In this study, using 91 SFT cases, we examined whether fusion variants are associated with clinicopathological parameters and also investigated the molecular mechanism of malignant transformation using whole-exome sequencing. We detected variant ...[more]