Ontology highlight
ABSTRACT:
SUBMITTER: Bi J
PROVIDER: S-EPMC6746770 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Bi Jianling J Yang Shujie S Li Long L Dai Qun Q Borcherding Nicholas N Wagner Brett A BA Buettner Garry R GR Spitz Douglas R DR Leslie Kimberly K KK Zhang Jun J Meng Xiangbing X
Cell death & disease 20190917 10
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death driven by lipid hydroperoxides within biological membranes. Although therapy-resistant mesenchymal-high cancers are particularly vulnerable to ferroptosis inducers, especially phospholipid glutathione peroxidase 4 (GPx4) inhibitors, the underlying mechanism is yet to be deciphered. As such, the full application of GPx4 inhibitors in cancer therapy remains challenging. Here we demonstrate that metadherin (MTDH) confers a ...[more]