Dataset Information

A Prospective Study on the Association Between Grip Strength and Cognitive Function Among Middle-Aged and Elderly Chinese Participants.

ABSTRACT: Objective:To study the efficacy of grip strength (GS) as a predictor of cognitive function in a large, nationwide sample of Chinese participants aged 45 years and above. Methods:We used data from three waves (W1, W2, and W3) fielded by the China Health and Retirement Longitudinal Study (CHARLS). Cognitive function was tested biennially and calculated using two categories: episodic memory and mental intactness. Demographics, health behaviors, and medical conditions were considered potential confounders. Using multivariate linear regression models (MLRMs), we examined the association between baseline GS (measure in W1) and cognitive function in W3. Using a generalized estimating equation (GEE), we examined baseline GS as a predictor of cognitive function change. Results:Total 9,333 individuals (53.2% women), with a mean baseline episodic memory score of 6.5, mean baseline mental intactness score of 7.2, and aged over 45 years (mean age = 58.6), were selected. The mean follow-up time was 4.0 years (range: 3.3-5.0 years). Using MLRMs and comparing the lowest GS score with the highest baseline GS score, we observed a significant correlation with a higher global cognitive function in both women (? = 1.061, p < 0.001) and men (? = 1.233, p < 0.001). After adjusting baseline global cognition, the highest GS level was still statistically significant in both women (? = 0.543, p < 0.05) and men (? = 0.742, p < 0.001). GEE suggested that the participants in the highest GS quartile had better cognitive performance over time in both women (? = 0.116, p = 0.030) and men (? = 0.143, p = 0.008) than those in the lowest quartile. Conclusion:Higher baseline level of GS was significantly related to better cognitive function and slowed the rate of its decline. Thus, it is an independent predictor of better cognitive status in middle-aged and elderly Chinese.

SUBMITTER: Liu Y

PROVIDER: S-EPMC6747049 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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A Prospective Study on the Association Between Grip Strength and Cognitive Function Among Middle-Aged and Elderly Chinese Participants.

Liu Yong Y Cao Xinyi X Gu Nannan N Yang Bixi B Wang Jijun J Li Chunbo C

Frontiers in aging neuroscience 20190910

<h4>Objective</h4>To study the efficacy of grip strength (GS) as a predictor of cognitive function in a large, nationwide sample of Chinese participants aged 45 years and above.<h4>Methods</h4>We used data from three waves (W1, W2, and W3) fielded by the China Health and Retirement Longitudinal Study (CHARLS). Cognitive function was tested biennially and calculated using two categories: episodic memory and mental intactness. Demographics, health behaviors, and medical conditions were considered ...[more]

PMID: 31551762

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Project description:BACKGROUND:Transient cognitive impairment is common in adult patients of all ages following anaesthesia and surgery. Apolipoprotein E (APOE) ?4 carriers may have a larger deterioration in short-term cognitive function after major surgery compared with APOE ?4 noncarriers. OBJECTIVES:The aim was to examine the effect of APOE ?4 on the association between exposure to surgery and anaesthesia, and subsequent cognitive functioning. A more pronounced deterioration in cognitive function in APOE ?4 carriers was hypothesised. DESIGN:An observational cross-sectional and a 6 to 10 years longitudinal twin cohort design. SETTING:Survey and register study of 2936 Danish twins aged 45 to 92 years. MAIN OUTCOME MEASURES:Cognitive function was assessed using five age-sensitive cognitive tests. In the cross-sectional study, we compared twins exposed to surgery with a reference group (unexposed). Linear regression models were used adjusting for sex and age and stratified by APOE ?4 carrier status. In the longitudinal cognitive follow-up study 1671 twins participated. Intrapair analyses were also performed using 70 same-sexed twin pairs concordant for APOE ?4 carrier status, but discordant for major surgery. RESULTS:APOE ?4 carriers had lower cognitive scores compared with noncarriers, and this was statistically significant in elderly twins 70+ years of age (mean difference, -0.67; 95% CI, -1.14 to -0.17). There was no significant impact on cognitive function after surgery according to APOE ?4 carrier status in the cross-sectional study. Similarly, there was no APOE ?4 modification in the longitudinal study. Also, in the intrapair analyses no evidence was found of lower cognitive score after major surgery compared with the nonexposed cotwins among APOE ?4 carriers. CONCLUSION:No evidence was found of more pronounced long-term deterioration in cognitive function after surgery among APOE ?4 carriers, but elderly APOE ?4 carriers in general performed worse on the cognitive tests than noncarriers.

Dataset Information

A Prospective Study on the Association Between Grip Strength and Cognitive Function Among Middle-Aged and Elderly Chinese Participants.

Publications

A Prospective Study on the Association Between Grip Strength and Cognitive Function Among Middle-Aged and Elderly Chinese Participants.

Similar Datasets

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